Dejan Lovren and Nathaniel Clyne are in contention to start for Liverpool after overcoming respective injuries, while Jurgen Klopp has refused to rule out either Adam Lallana (groin) or Georginio Wijnaldum (hamstring).
All of Manchester United's internationals returned without any concerns and both Luke Shaw and Henrikh Mkhitaryan are available after injury.
Did you know?
Liverpool have lost more Premier League matches (27) against Manchester United than versus any other opponent.
Indeed, Liverpool have lost each of their last four PL meetings with Man Utd, their worst league losing streak against the Red Devils since March 2008 (five defeats).
Only Steven Gerrard (8) has scored more goals in this Premier League fixture than Wayne Rooney (6, level with Robbie Fowler).
Wayne Rooney currently has 87 Premier League away goals, the joint-most in the competition alongside Alan Shearer.
What the managers say
Jurgen Klopp on the enormity of the fixture: “It will never – not for as long as I live, for sure - be a normal game and so we should use this opportunity on the pitch."
See: Klopp's injury update | Klopp press conference in full
Jose Mourinho: "I always like to play at Anfield. I've won big matches and lost big matches there. I like the atmosphere and the characteristics of the matches."
See: Mourinho's press conference recap | Jose excited by rivalry
