Watford head coach Nigel Pearson takes charge of his first home match looking to secure the Hornets' first Vicarage Road victory of the season.
Manchester United are seeking to extend their six-match unbeaten run and close the gap on fourth-placed Chelsea, who are currently four points ahead.
Team news
Watford's Adam Masina (thigh) and Roberto Pereyra (groin) could be in contention after returning to training this week.
Jose Holebas is ruled out with an ankle problem and joins long-term absentees Tom Cleverley (heel), Danny Welbeck (hamstring), Sebastian Prodl (knee) and Daryl Janmaat (knee) on the sidelines.
Man Utd's Paul Pogba has returned to full training following a knee injury and continues to be monitored.
Diogo Dalot (groin) has stepped up his training, but lacks match fitness, while Eric Bailly (knee) remains sidelined.
Did you know?
Man Utd have won 11 of their 12 Premier League meetings (92 per cent) with Watford. Only against Wigan Athletic do they have a higher win rate (94 per cent) of teams they have played at least 10 times.
Marcus Rashford has scored 10 Premier League goals this season, one more than Watford. The last Man Utd player to score more before Christmas in a campaign was Zlatan Ibrahimovic, with 11 in 2016/17.
Nigel Pearson’s only previous home Premier League encounter against Man Utd was in September 2014, winning 5-3 with Leicester City. Only six managers have won their first two home matches against the Red Devils in the Premier League, most recently Antonio Conte in 2017.
After going six league matches unbeaten against United between 1984 and 1986, Watford have lost 14 of their last 15 against the Red Devils in the top flight (W1).
Match officials
Referee: Lee Mason. Assistants: Scott Ledger, Simon Long. Fourth official: Graham Scott. VAR: Martin Atkinson. Assistant VAR: Stephen Child.