Ahead of Matchweek 6's Premier League fixtures, here are the standout facts on each match.
Click on the fixtures to see head-to-head records, past meetings and form guides.
Saturday, 22 September
Fulham v Watford
No side have scored more second-half PL goals than Watford this season, with Chelsea matching the Hornets' eight. Only West Ham United, with seven, have conceded more than Fulham's six after the interval.
Burnley v AFC Bournemouth
AFC Bournemouth's haul of 10 points from their first five fixtures is their best start to a league season since the 2009/10 League Two campaign, when they had 12.
Cardiff City v Manchester City
This will be the third PL meeting between Cardiff and Man City, with the previous two providing 11 goals; the Bluebirds winning 3-2 at home and losing 4-2 at the Etihad in 2013/14.
Crystal Palace v Newcastle United
Palace have won only one of their last 10 PL matches against Newcastle.
Leicester City v Huddersfield Town
Jamie Vardy has found the net in his last two league appearances against Huddersfield.
Liverpool v Southampton
Liverpool are looking to start a top-flight campaign with six consecutive wins for the third time in their history, after 1978/79, when they finished first, and 1990/91, when they came second.
Man Utd v Wolves
Wolves have won their last two Premier League matches, both by a 1-0 scoreline. They have not won three in a row in the top flight since March 1980.
Brighton v Spurs
Seagulls striker Glenn Murray has scored four goals in his five PL matches this season, including three in two at the Amex Stadium.
Sunday, 23 September
West Ham v Chelsea
Chelsea's Maurizio Sarri could become only the third head coach or manager to win his first six PL matches in charge, after Carlo Ancelotti and Pep Guardiola.
Arsenal v Everton
Arsenal are unbeaten in 24 home matches against Everton in all competitions (W20 D4) since a 2-1 PL defeat in January 1996 under Bruce Rioch.