Team news
Anthony Martial could be in Manchester United's starting XI after returning from injury as a second-half substitute in the Manchester derby last weekend.
Did you know?
Sheffield United beat Man Utd on the Premier League's opening weekend in 1992 but are winless in seven meetings in the competition since (D1 L6).
Sheff Utd are one of only four teams in English league history to have one point or fewer after 12 matches of a season, in any division. Man Utd were the first side to suffer such a start, in the top flight in 1930/31.
Victory for Man Utd would make them the fourth side in top-flight history to win 10 away league matches in a row, after Tottenham Hotspur, Chelsea and Manchester City.
Bruno Fernandes has featured in four Premier League matches against teams starting the day in the relegation zone. He has scored four goals and set up another four, averaging a goal or assist every 43 minutes.
Match officials
Referee: Michael Oliver. Assistants: Stuart Burt, Simon Bennett. Fourth official: Robert Jones. VAR: Paul Tierney. Assistant VAR: Harry Lennard.