After Tuesday's wins for Arsenal and Aston Villa and Liverpool's victory on Wednesday night, football writer Ben Bloom looks at the remainder of this week's European ties featuring Premier League sides and what to expect in the knockout stages.
As the days lengthen and temperatures start to rise, European competitions reach their business end with the arrival of the round of 16.
Of the seven Premier League clubs that entered the UEFA Champions League, UEFA Europa League and UEFA Conference League, only Manchester City, who fell to Real Madrid in the Champions League playoff stage, have not progressed.
But Aston Villa, Arsenal and Liverpool remain in Europe’s leading competition, while Tottenham Hotspur, Manchester United and Chelsea all have their eyes on other continental silverware.
The English contingent are not only fighting for quarter-final places, but also bidding to help the Premier League earn an additional fifth spot in next season’s Champions League.
Who stands in their way and what chance do they have of keeping their dreams alive? Here is everything you need to know ahead of this week's remaining European matches.
Europa League round-of-16 ties
AZ Alkmaar v Tottenham Hotspur
First leg: AZ Alkmaar v Spurs, Thursday 6 March, 17:45 GMT
Second leg: Spurs v AZ Alkmaar, Thursday 13 March, 20:00 GMT
While Spurs' injury crisis – which has started to abate – has seen them struggle in the Premier League, Ange Postecoglou’s team have lost only once in the Europa League, qualifying for this match in fourth place.
They now face an AZ Alkmaar side who they beat 1-0 during the league phase, when striker Troy Parrott returned to face his former club.
The Dutch team saw off Galatasaray in the knockout playoffs, but lost their first game in eight matches across all competitions at the weekend.
Languishing in 13th in the Premier League, winning the Europa League arguably represents Spurs’ best chance of European football next season.
Real Sociedad v Manchester United
First leg: Real Sociedad v Man Utd, Thursday 6 March, 17:45 GMT
Second leg: Man Utd v Real Sociedad, Thursday 13 March, 20:00 GMT
Like Spurs, this is Man Utd’s sole remaining chance of silverware after Fulham knocked them out of the FA Cup last weekend.
United also cruised through to the Europa League last 16 as the only undefeated team in the competition, advancing in third place.
Their reward is a meeting with Real Sociedad, who have not progressed beyond this stage of any European competition since 1989.
The Spanish side, who feature former Man City man Sergio Gomez and West Ham loanee Nayef Aguerd, finished 13th in the league phase before easing past Midtjylland in the knockout play-offs. Six defeats in their last nine LaLiga games have left them ninth in the table.
Conference League round-of-16 tie
F.C. Copenhagen v Chelsea
First leg: Copenhagen v Chelsea, Thursday 6 March, 17:45 GMT
Second leg: Chelsea v Copenhagen, Thursday 13 March, 20:00 GMT
Despite fielding a largely second-string side throughout the league phase, Chelsea eased to a perfect record of six wins from six to top the Conference League table.
Copenhagen won only two of their league-phase games, before beating Heidenheim in the playoffs to reach the last 16. They are currently top of the Danish Superliga and unbeaten in 10 domestic league matches.
Chelsea, meanwhile, have lost three of their last five Premier League games, but still sit fifth, two points off third place.
