Stoke City are without central defenders Bruno Martins Indi (groin) and Ryan Shawcross (back), while Kevin Wimmer (thigh) is unlikely to be fit.
Geoff Cameron has a chance of returning from a hamstring injury and Kurt Zouma is available after being ineligible for Matchweek 6.
Southampton have no new injuries and centre-back Virgil van Dijk is in contention for a first start.
Did you know?
Stoke City have won only three of their last 15 home matches against Southampton in all competitions (D5 L7).
Ten of Southampton’s 11 Premier League goals against Stoke have been scored in the first half, and none have come later than the 57th minute.
Southampton are on a four-match unbeaten away run in the Premier League (W2 D2) – their longest streak since six matches in November 2015.
Saints have kept a clean sheet in their opening two away matches. They’ve never kept clean sheets in their opening three away from home in any of their previous 90 seasons in the Football League.
What the managers say
Mark Hughes: "It will be a difficult game but given what we've faced so far at home it's one we can look forward to and enjoy."
See: Hughes hopeful on Cameron
Mauricio Pellegrino: "We have been working well this week. Every single game is an opportunity to show how we are."
Referee: Mike Jones
Assistants: Simon Beck, Derek Eaton
Fourth official: Bobby Madley