Arsenal will make a late decision on whether Mesut Ozil has recovered after illness kept him out of the victory over Burnley.
Alex Iwobi (dead leg) is a doubt but there are no other new injury concerns.
Huddersfield Town will be without midfielder Rajiv van La Parra following his red card against Man City.
Philip Billing (ankle), Michael Hefele (knee) and Jon Gorenc Stankovic (Achilles) are the club's long-term absentees.
Did you know?
Arsenal have won 11 Premier League home matches in a row - their best since a run of 13 at Highbury Stadium between February and November 2005.
Huddersfield Town are hoping to become only the third team, after West Ham United and Hull City, to win their first PL match at Emirates Stadium.
The Terriers could also become only the second newly-promoted team in PL history to beat both Arsenal and Manchester United in that season, after Sunderland in 1996/97.
Alexis Sanchez has been directly involved in 17 goals in 18 PL matches against promoted clubs (13 goals, four assists).
What the managers say
Arsene Wenger: "With all the teams that come up, you realise that especially in the first season they have that kind of fighting spirit that makes them dangerous for every Premier League side."
See: Wenger on his side unbeaten's home run
David Wagner: "We have, like always, the obligation that we invest everything, try everything, do everything what we can do and then we will see what we can get out of this game."
See: We have belief going into every match - Wagner
Referee: Graham Scott
Assistants: Peter Kirkup, Constantine Hatzidakis
Fourth official: Kevin Friend
