Wilfred Ndidi (hamstring), Matty James (Achilles), Daniel Amartey (hamstring) and Robert Huth (ankle) are all out for Leicester City.
Marc Albrighton will also miss the club's remaining two matches after accepting an FA charge of misconduct.
Vicente Iborra (hamstring), Fousseni Diabate (illness), Danny Simpson (pelvis), Aleksandar Dragovic (shoulder), Ben Chilwell, Shinji Okazaki, and Kasper Schmeichel (all ankle) are facing late fitness tests.
Arsenal will be without captain Laurent Koscielny, who has been sidelined for six months after surgery on his Achilles injury.
Santi Cazorla (Achilles) is training again but will not be risked, Mohamed Elneny (ankle) is out and Mesut Ozil (back) is unlikely to feature again this season.
Did you know?
After Leicester City won their first Premier League meeting with Arsenal, in November 1994, a 2-1 victory at Filbert Street, they’ve failed to beat them in any of the 22 meetings since (D7 L15).
Arsenal’s 22-match unbeaten league run against the Foxes is their longest run against an opponent in their top-flight history.
Claude Puel has lost his two previous home meetings against Arsenal by an aggregate score of 0-7, both as Southampton manager (0-5 in the FA Cup in January 2017 and 0-2 in the Premier League in May 2017).
Jamie Vardy has five goals in his last five Premier League matches against Arsenal, scoring twice in the reverse fixture.
Club previews
Leicester: Fuchs: We will push hard
Arsenal: Wenger: I've had more offers than I expected
Referee: Graham Scott
Assistants: Lee Betts, Marc Perry
Fourth official: Craig Pawson
