Unai Emery has been handed a baptism of fire as the new head coach of Arsenal.
The Spaniard, who took over from Arsene Wenger this summer, will face the past two Premier League champions in his first two matches in charge at Arsenal.
The release of the 2018/19 Premier League fixtures has pitted the Gunners at home to Manchester City on the opening weekend of 11 and 12 August before a trip to Chelsea the following weekend.
Man Utd host Leicester
Last season's runners-up, Manchester United, welcome 2015/16 champions Leicester City to Old Trafford, while in a repeat of last season's Matchweek 1 fixture, Tottenham Hotspur will travel to Newcastle United, where they won 2-0.
Molineux hosts Premier League football for the first time in six years as Wolverhampton Wanderers, the winners of last season's Championship, host Marco Silva's Everton side.
Of the other promoted sides, Fulham start at home to Crystal Palace, which is the same fixture they finished their last Premier League campaign with in 2013/14.
Cardiff City are on the road for their first match, travelling to AFC Bournemouth.
Southampton first?
New West Ham United manager Manuel Pellegrini faces a tough start at Liverpool, while Southampton will be hoping to earn their first Premier League home win in Matchweek 1 when Burnley travel to St Mary's Stadium.
Huddersfield Town will host Chelsea, against whom they secured their Premier League status at the end of last season with a 1-1 draw at Stamford Bridge.
Vicarage Road was where Brighton & Hove Albion earned their first PL point last season and they open there against a Watford team seeking a first Matchweek 1 victory.
See: 2018/19 Premier League fixtures
Matchweek 1
Arsenal v Man City
AFC Bournemouth v Cardiff City
Fulham v Crystal Palace
Huddersfield Town v Chelsea
Liverpool v West Ham
Man Utd v Leicester City
Newcastle United v Spurs
Southampton v Burnley
Watford v Brighton
Wolves v Everton
Fixture-release content
Part 1: Premier League fixtures for 2018/19 announced
Part 3: London and Merseyside set for triple derby special
Part 4: Goals and shocks in store on Boxing Day
Part 5: Will City avoid unwanted champions' hat-trick?
Part 6: Promoted clubs eye historic winning treble
Part 7: Top five set for late-season showdowns
Part 8: Tough finishes can inspire Wagner and Hughton
Part 9: Drogba the last of the MW1 hat-trick heroes