Dele Alli scored a first-half penalty for Tottenham Hotspur to make it a winning return to Molineux for former Wolverhampton Wanderers head coach Nuno Espirito Santo.
Spurs broke the deadlock on nine minutes when midfielder Dele side-footed home from the spot after being fouled by Jose Sa.
Raul Jimenez, making his first home Premier League appearance since 23 November 2020, went close to equalising after 27 minutes but curled over from Joao Moutinho's low square ball.
Nelsen Semedo also cleared the bar before Jimenez and Adama Traore were both denied by Spurs goalkeeper Hugo Lloris, making his club-record 300th PL appearance.
Steven Bergwijn and Son Heung-min then went close for the visitors as the teams traded second-half chances.
Spurs substitute Harry Kane, making his first appearance of the season, nearly made it 2-0, but his 81st-minute effort was saved by Sa.
See: Wolves report | Spurs report
Next fixtures
Wolves: 29 Aug v Man Utd (H)
Spurs: 29 Aug v Watford (H)
Match officials
Referee: Stuart Attwell. Assistants: Dan Cook, Marc Perry. Fourth official: Peter Bankes. VAR: Martin Atkinson. Assistant VAR: James Mainwaring
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