Crystal Palace could become only the second club to complete a Premier League double over a Man City side managed by Pep Guardiola, having won 3-2 at the Etihad Stadium in December. Chelsea in 2016/17 are the only side to have so far achieved this feat.
Second-placed City have won their last eight matches, scoring 20 and conceding just two.
Team news
Palace's James Tomkins (groin) will miss the rest of the season after undergoing surgery, while his fellow centre-back Mamadou Sakho (knee) is also out of action.
Pep Guardiola will assess the fitness of Oleksandr Zinchenko and Bernardo Silva to see if they are ready to return from injury.
Did you know?
Luka Milivojevic has scored 10 penalty goals in the Premier League this season. Only Andrew Johnson, who scored 11 in 2004/05 also for Palace, has netted more from the spot in a single campaign.
Man City boss Pep Guardiola is winless in his last two PL meetings with Crystal Palace – he has only ever had longer winless league runs against Everton (3) and Borussia Mönchengladbach (4) in his entire managerial career.
Crystal Palace have won just 41 per cent of their Premier League points in home games this season (16/39), the lowest such ratio in the division.
Sergio Aguero has scored 20 PL goals in London. Only Wayne Rooney (30) has scored more when excluding players for London clubs. However, Aguero has failed to score in his five PL appearances at Selhurst Park.
Referee: Martin Atkinson
Assistants: Lee Betts, Adam Nunn
Fourth official: David Coote