Arsenal striker Olivier Giroud (toe) and midfielder Aaron Ramsey (hamstring) remain sidelined, but Francis Coquelin is back following a knee injury.
For Swansea City Fernando Llorente (knee), the striker, and winger Jefferson Montero (calf) are both doubtful, while Nathan Dyer is definitely out.
Did you know?
Arsenal have enjoyed only one win in their last five Premier League meetings with Swansea, losing three and drawing one.
Indeed, at Emirates Stadium, Swansea are unbeaten in their last four visits in the Premier League (W3 D1).
Arsenal's PL average of 0.8 points per home match to Swansea is their worst return on home soil against any side. Conversely, the Swans' two-point average in this fixture is the best return for any visiting side at Emirates Stadium.
Swansea's new manager, Bob Bradley, will be the first American manager to oversee a Premier League match.
What the managers say
Arsene Wenger: "Last year we had a very negative experience with Swansea who killed our opportunity to win the Premier League. We have a good opportunity to show that we have learned from that."
See: Team news: Ozil, Giroud and Ramsey
Bob Bradley: "To win there we will have to play well — all the details need to be right. We have to make sure that defensively, the distance between our lines is right and our awareness is right."