AFC Bournemouth are aiming to make a winning start for the second season in a row, while Sheffield United are making their Premier League return after a 12-year absence.
Team news
Eddie Howe is unable to call on David Brooks and Lloyd Kelly (both ankle) and Dan Gosling (hip), while Simon Francis, Lewis Cook and Junior Stanislas (all knee) remain long-term absentees.
But defensive duo Steve Cook and Charlie Daniels are available following injury.
Chris Wilder has a fully-fit Sheffield United squad to pick from, including deadline-day signings Michael Verrips and Mo Besic.
Did you know?
AFC Bournemouth won their opening Premier League fixture last season, also at home against a promoted side, Cardiff City. They had previously lost each of their three opening-weekend matches in the competition.
Sheffield United have lost four of their last five opening league fixtures. But they are unbeaten in all three of their Premier League openers, winning twice.
AFC Bournemouth have only lost one of their 11 Premier League home matches against promoted sides (W7 D3), although that defeat came in their last such match, against Fulham in April.
Since the start of the 2005/06 campaign, Sheffield United striker Billy Sharp has scored more league goals than any other player in the top four tiers of English football, with 218.
Referee: Kevin Friend
Assistants: Matthew Wilkes, Nick Hopton
Fourth official: Charles Breakspear
VAR: Lee Mason
Assistant VAR: Andy Halliday