Liverpool have played the bottom side only once as leaders but on that occasion lost 2-1 at Tottenham Hotspur.
Here are all the results between the clubs at the top of the Premier League and those in last place.
Premier League leaders v bottom-placed sides
| Date | Top | Bottom | F | A | Result |
|---|---|---|---|---|---|
| 27/01/93 | Man Utd | Nott'm For | 2 | 0 | W |
| 09/03/93 | Man Utd | Oldham | 0 | 1 | L |
| 25/09/93 | Man Utd | Swindon | 4 | 2 | W |
| 19/03/94 | Man Utd | Swindon | 2 | 2 | D |
| 16/09/95 | Newcastle | Man City | 3 | 1 | W |
| 20/01/96 | Newcastle | Bolton | 2 | 1 | W |
| 14/11/98 | Aston Villa | Southampton | 4 | 1 | W |
| 06/02/99 | Man Utd | Nott'm For | 8 | 1 | W |
| 16/10/99 | Leeds | Sheff Wed | 2 | 0 | W |
| 29/04/00 | Man Utd | Watford | 3 | 2 | W |
| 13/01/01 | Man Utd | Bradford | 3 | 0 | W |
| 23/08/03 | Blackburn | Bolton | 2 | 2 | D |
| 06/12/03 | Chelsea | Leeds | 1 | 1 | D |
| 17/01/04 | Man Utd | Wolves | 0 | 1 | L |
| 10/09/05 | Chelsea | Sunderland | 2 | 0 | W |
| 23/10/05 | Chelsea | Everton | 1 | 1 | D |
| 15/01/06 | Chelsea | Sunderland | 2 | 1 | W |
| 31/01/07 | Man Utd | Watford | 4 | 0 | W |
| 31/08/08 | Chelsea | Spurs | 1 | 1 | D |
| 01/11/08 | Liverpool | Spurs | 1 | 2 | L |
| 15/11/08 | Chelsea | West Brom | 3 | 0 | W |
| 27/01/09 | Man Utd | West Brom | 5 | 0 | W |
| 16/12/09 | Chelsea | Portsmouth | 2 | 1 | W |
| 11/09/10 | Chelsea | West Ham | 3 | 1 | W |
| 05/02/11 | Man Utd | Wolves | 1 | 2 | L |
| 16/01/12 | Man City | Wigan | 1 | 0 | W |
| 23/02/13 | Man Utd | QPR | 2 | 0 | W |
| 01/03/14 | Chelsea | Fulham | 3 | 1 | W |
| 08/11/15 | Man City | Aston Villa | 0 | 0 | D |
| 14/12/16 | Chelsea | Sunderland | 1 | 0 | W |
| 21/05/17 | Chelsea | Sunderland | 5 | 1 | W |
| 23/09/17 | Man City | Crystal Palace | 5 | 0 | W |
| 13/12/17 | Man City | Swansea | 4 | 0 | W |
| 31/01/18 | Man City | West Brom | 3 | 0 | W |
