A shoulder injury to Kevin De Bruyne (£10.7m) looks set to further raise the armband appeal of Pierre-Emerick Aubameyang (£11.0m) in Fantasy Premier League.
Manchester City and Arsenal are the only two teams with two fixtures in Gameweek 29.
Pep Guardiola's side visit Manchester United on Sunday before hosting the Gunners, who are at home to West Ham United prior to their midweek contest at the Etihad Stadium.
However, De Bruyne is an injury doubt, having missed Man City's midweek FA Cup win at Sheffield Wednesday.
Late decision?
The top-scoring player in FPL, De Bruyne is also the most-owned, sitting in 50.1 per cent of squads.
He produced his season-high haul of 19 points against the Gunners in Gameweek 17, scoring twice and supplying an assist in a 3-0 win.
But many could be reluctant to hand De Bruyne the captaincy if he remains a doubt ahead of Saturday’s 11:30 GMT deadline.
The news from Guardiola's press conference on Friday afternoon may be decisive in how managers select their captain.
Aubameyang's current form suggests he will be De Bruyne's main rival.
Impressive average
He has scored six goals in seven appearances for the Gunners under Mikel Arteta, averaging 6.4 points per match.
The Gabon international produced 12 points in his previous meeting with West Ham, find the net and providing an assist in Gameweek 16.
Furthermore, Arsenal appear less likely to rotate than Man City after their recent exit from the UEFA Europa League.
Aguero and Pepe attractive options
There are further in-form alternatives from both sides worth considering.
Man City forward Sergio Aguero (£11.9m) has six goals in the last six Gameweeks, totalling 41 points.
Nicolas Pepe (£9.2m) is another option, having returned 22 points in Arsenal's last two matches with a goal and three assists.
Having blanked in his last five outings, Raheem Sterling (£11.7m) represents a somewhat riskier option.
But, like his team-mate De Bruyne, he claimed a double-figure haul against the Gunners earlier this season.
And with an ownership of just 15 per cent, Sterling could prove a powerful differential over the Double Gameweek.
What the experts say
Holly Shand (@FFCommunity_): With news of a Double Gameweek and De Bruyne currently doubtful, it's an easy decision to captain Aubameyang. Mohamed Salah (£12.8m) could punish us for overlooking his single fixture.
Paul Gee (@FplPaulGee): If De Bruyne misses out then it's probably Aubameyang. Don't forget the usual Liverpool assets, who could bounce back.
Sam Bonfield (@FPLFamily): If De Bruyne is missing this weekend that limits my captaincy options. Currently that would only leave me with Aubameyang playing a Double Gameweek and, as such, he will get the armband. There are good single Gameweek options out there too. The likes of Salah shouldn't be overlooked.
Ben Crabtree (@FC_CrabDogg): It looks like I'll be going with Aguero. It feels a risk but if he starts, he'll be motivated to earn UEFA Champions League starts.
Chuck Booth (@ChuckBoothSport): Man City and Arsenal getting a Double Gameweek is making me move my captaincy for the first time in about six weeks to De Bruyne. Realistically, my top options are him and Aubameyang but I can't blow up my entire midfield just for a few weeks of Aubameyang.
Ben McNair (@drbenmcnair): De Bruyne looks the safe option. He may not start both games but he's a viable captain with one game, let alone two. Managers looking for high-risk options have some great choices in Aguero and Aubameyang.
Geoff Dance (@GeoffreyDance): I'm tempted to captain a Liverpool player, either Salah or Sadio Mane (£12.4m), but I will likely buy Aubameyang for a four-point hit and captain him. I expect him to profit, particularly against West Ham.
Neal Thurman (@nealjthurman): It's hard not to be in on Aubameyang, with Arsenal having two fixtures this week, and West Ham being one of them.