Manchester City will aim to bounce back from their 2-1 loss at Chelsea, taking heart from the fact they have won both their home matches since the Premier League returned.
Liverpool will be playing their first fixture since being crowned champions and can complete the league double over Pep Guardiola's side.
Team news
Eric Garcia and John Stones could return for Man City after overcoming head and ankle injuries respectively, but Sergio Aguero (knee) remains sidelined. Fernandinho misses out due to suspension.
Liverpool are without defender Joel Matip, who expects to miss the rest of the season with a foot injury.
Did you know?
This will be only the third meeting between newly-crowned Premier League champions and the previous title-winners before the end of a season. Manchester United and Leicester City each faced Chelsea after replacing the Blues as champions in May 2007 and 2016 respectively.
Man City have won their last two Premier League home meetings with Liverpool. They can now make it three in a row in the top flight for the first time since 1937.
Liverpool are looking to complete a Premier League double over Manchester City for just the third time, having previously done so in 2005/06 and 2015/16.
If Mohamed Salah finds the net or provides an assist, he will become the second-fastest player to reach 100 Premier League goal involvements, reaching the mark in his 115th match. Alan Shearer achieved the century in 100 matches.
Match officials
Referee: Anthony Taylor. Assistants: Gary Beswick, Adam Nunn. Fourth official: Mike Dean. Replacement official: Akil Howson. VAR: Stuart Attwell. Assistant VAR: Stephen Child.