Aston Villa are looking to win three consecutive Premier League matches for the first time since April 2010.
Liverpool can be the first team in top-flight history to start three consecutive campaigns with four victories in a row.
Team news
Villa's Kortney Hause will be assessed after he came off in Thursday night's Caraboa Cup defeat by Stoke City.
Ross Barkley could make his debut after joining from Chelsea on loan this week.
Jordan Henderson is now recovered from a muscle injury that had kept the Liverpool captain sidelined since 20 September.
Sadio Mane has tested positive for COVID-19 and is currently self-isolating according to the necessary guidelines. Thiago Alcantara continues to follow COVID-19 protocols and will not feature.
Did you know?
If Jack Grealish scores for Aston Villa it will be the first time he has netted in back-to-back matches in the competition since October 2019.
Dean Smith's men are unbeaten in their last six league matches (W4 D2), the longest current run in the competition.
Liverpool have lost just one of their last 19 Premier League trips to Villa Park (W13 D5), claiming victories on their last six visits since a 1-0 defeat in May 2011.
Sadio Mane has scored six goals in his six top-flight matches against Villa, bettered only by his total of nine goals versus Crystal Palace (nine) and seven against Arsenal.
Match officials
Referee: Martin Atkinson. Assistants: Constantine Hatzidakis, Richard West. Fourth official: David Coote. VAR: Jonathan Moss. Assistant VAR: Stephen Child.