Tyrone Mings (£5.0m) was among a number of defenders to produce double-digit Fantasy Premier League returns in Saturday's matches.
The Aston Villa centre-back is the top-scoring player in Gameweek 2, delivering his career-high haul of 15 points.
Mings produced two FPL assists and earned the maximum three bonus points in a 2-0 win over Newcastle United.
Tsimikas stars despite Robertson return
Home defences dominated Saturday's six matches, with five away sides failing to score.
Full-backs Trent Alexander-Arnold (£7.5m) and Konstantinos Tsimikas (£4.1m) each supplied an assist in Liverpool's 2-0 win over Burnley at Anfield, claiming 12 and 11 points respectively.
Liverpool 2-0 Burnley highlights
The cut-price Tsimikas remains a top target for managers, despite the return of team-mate and fellow left-back Andrew Robertson (£7.0m) to the bench.
Tsimikas is the most-bought player in the Gameweek, earning more than 82,000 new owners.
Centre-back success
Shane Duffy (£4.0m) has also been a big success as a budget defender.
He earned 14 points in Brighton & Hove Albion's 2-0 win over Watford, scoring and earning three bonus.
Meanwhile, Aymeric Laporte (£5.5m) and Ruben Dias (£6.0m) were the top performers in Manchester City’s 5-0 win over Norwich City.
The centre-backs produced a goal and assist respectively, with Laporte bettering Dias by 14 points to 11.
Man City 5-0 Norwich highlights
Their team-mate Gabriel Jesus (£8.5m) was the only midfielder or forward to produce a double-figure haul on Saturday.
Playing on the wing, the Brazilian striker recorded two assists in his first start of the campaign to earn 11 points.
Calvert-Lewin boost for strong schedule
Everton were the only away side to score on Saturday.
Dominic Calvert-Lewin (£8.1m) opened the scoring from the penalty spot in their 2-2 draw at Leeds United.
That suggests the forward is now on spot-kick duties for new head coach Rafa Benitez ahead of a very favourable schedule.
Only one of Everton's next eight matches scores more than three in the Fixture Difficulty Ratings (FDR).
SCOUT: Dominic Calvert-Lewin has mustered nine shots in the box over the first two Gameweeks, more than any other player
— Fantasy Premier League (@OfficialFPL) August 22, 2021
Are you considering bringing him in?#FPL pic.twitter.com/M7pDbvqSjq
Calvert-Lewin is among only four players to score in each of the first two Gameweeks of the new season, having also netted against Southampton last weekend.
Aston Villa’s Danny Ings (£8.0m) and Brighton’s Neal Maupay (£6.5m) are the other two forwards to achieve this feat, along with Liverpool midfielder Diogo Jota (£7.5m).
Also in this series
Part 1: FDR Analysis: Everton can build momentum
Part 2: GW2 FPL stats: Lukaku outscores Salah and Fernandes
Part 3: GW2 Bonus points: West Ham duo add to scores
Part 5: GW2 Lessons: Jota can help you get Lukaku
Part 6: FPL experts: What to do with Tsimikas and Jota?
Part 7: GW2 Lessons: Dias can avoid Pep rotation