Sadio Mane scored the decisive spot-kick and Edouard Mendy made a crucial save as Senegal beat Egypt 4-2 on penalties to clinch their first-ever Africa Cup of Nations.
The Chelsea goalkeeper saved Mohanad Lasheen's penalty to put Senegal in control of the shootout before Mane found the bottom-left corner to seal a famous victory.
Mane redeemed himself after having a seventh-minute penalty saved by Egypt goalkeeper Gabaski in a contest where chances were at a premium, with Mohamed Salah twice being denied by Mendy as it finished goalless following extra-time.
Liverpool winger Mane was named player of the tournament while Mendy picked up the goalkeeper of the tournament award.
🏆 #AFCON2021 𝗖𝗛𝗔𝗠𝗣𝗜𝗢𝗡𝗦 🏆
— Liverpool FC (@LFC) February 6, 2022
Congratulations Sadio Mane and #TeamSenegal 👏 pic.twitter.com/kriocxmwgK
Watford winger Ismaila Sarr, Crystal Palace's Cheikhou Kouyate and Leicester City midfielder Nampalys Mendy also started for Senegal and pick up winners' medals.
Arsenal's Mohamed Elneny played all 120 minutes for Egypt while Aston Villa winger Trezeguet came on as a second-half substitute.
Salah and Mane could return to Premier League action on Thursday when Liverpool host Leicester.
In the third-place playoff, Aston Villa winger Bertrand Traore provided an assist but ended up on the losing team as Burkina Faso were beaten 5-3 on penalties by hosts Cameroon following a 3-3 draw after extra-time.
PL players who featured at AFCON
Algeria Riyad Mahrez (MCI), Said Benrahma (WHU)
Burkina Faso Bertrand Traore (AVL)
Côte d'Ivoire Eric Bailly (MUN), Maxwel Cornet (BUR), Willy Boly (WOL), Nicolas Pepe (ARS), Wilfried Zaha (CRY)
Egypt Mohamed Elneny (ARS), Trezeguet (AVL), Mohamed Salah (LIV)
Gabon Pierre-Emerick Aubameyang (ARS), Ulrick Eneme-Ella (BHA)
Ghana Daniel Amartey (LEI), Thomas Partey (ARS), Jordan Ayew (CRY)
Guinea Naby Keïta (LIV)
Mali Moussa Djenepo (SOU), Yves Bissouma (BHA)
Morocco Romain Saïss (WOL); Adam Masina (WAT), Imran Louza (WAT)
Nigeria William Troost-Ekong (WAT), Alex Iwobi (EVE), Wilfred Ndidi (LEI), Frank Onyeka (BRE), Kelechi Iheanacho (LEI)
Senegal Edouard Mendy (CHE); Cheikhou Kouyate (CRY), Nampalys Mendy (LEI), Sadio Mane (LIV), Ismaila Sarr (WAT)
Tunisia Omar Rekik (ARS), Hannibal Mejbri (MUN)