An away victory would leave Manchester City within a point of winning their eighth top-flight title, their sixth in the Premier League, and their fourth in the last five seasons.
West Ham United, meanwhile, are hoping to leapfrog Manchester United into sixth place. David Moyes' side currently sit in seventh, three points behind the Red Devils with two matches remaining, and a match in hand.
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Did you know?
Man City have become the first team in English top-flight history to win five consecutive league matches by a margin of at least three goals.
West Ham won their last Premier League match against the league leaders, defeating Chelsea 3-2 in December. They have not won consecutive such matches since doing the double over Manchester United in 2006/07, while they have not beaten two different teams at the top of the table in a campaign since 1982/83 (Liverpool and Man Utd).
Man City's Raheem Sterling has been involved in 14 goals in 16 Premier League matches against West Ham, with eight goals and six assists, more than he has versus any other side. Nine of these have come in five appearances at the London Stadium where he has produced four goals and five assists, including a hat-trick in August 2019.
The Hammers have scored in all 18 of their Premier League home matches this season. Only twice have they managed to score in 100 per cent of their home matches across an entire league season, doing so in 1980/81 in the second tier, and in 1926/27 in the top flight.
Match officials
Referee: Anthony Taylor. Assistants: Gary Beswick, Adam Nunn. Fourth official: Graham Scott. VAR: John Brooks. Assistant VAR: Simon Long.