Here is how each of the Premier League champions kicked off their title-winning campaigns.
Eventual champions' opening result
| Season | Eventual champions | Opponent | Result | Score |
| 1992/93 | Man Utd | Sheff Utd (A) | L | 2-1 |
| 1993/94 | Man Utd | Norwich (A) | W | 0-2 |
| 1994/95 | Blackburn | Southampton (A) | D | 1-1 |
| 1995/96 | Man Utd | Aston Villa (A) | L | 3-1 |
| 1996/97 | Man Utd | Wimbledon (A) | W | 0-3 |
| 1997/98 | Arsenal | Leeds (A) | D | 1-1 |
| 1998/99 | Man Utd | Leicester (H) | D | 2-2 |
| 1999/00 | Man Utd | Everton (A) | D | 1-1 |
| 2000/01 | Man Utd | Newcastle (H) | W | 2-0 |
| 2001/02 | Arsenal | Middlesbrough (A) | W | 0-4 |
| 2002/03 | Man Utd | West Brom (H) | W | 1-0 |
| 2003/04 | Arsenal | Everton (H) | W | 2-1 |
| 2004/05 | Chelsea | Man Utd (H) | W | 1-0 |
| 2005/06 | Chelsea | Wigan (A) | W | 0-1 |
| 2006/07 | Man Utd | Fulham (H) | W | 5-1 |
| 2007/08 | Man Utd | Reading (H) | D | 0-0 |
| 2008/09 | Man Utd | Newcastle (H) | D | 1-1 |
| 2009/10 | Chelsea | Hull (H) | W | 2-1 |
| 2010/11 | Man Utd | Newcastle (H) | W | 3-0 |
| 2011/12 | Man City | Swansea (H) | W | 4-0 |
| 2012/13 | Man Utd | Everton (A) | L | 1-0 |
| 2013/14 | Man City | Newcastle (H) | W | 4-0 |
| 2014/15 | Chelsea | Burnley (A) | W | 1-3 |
| 2015/16 | Leicester | Sunderland (H) | W | 4-2 |
| 2016/17 | Chelsea | West Ham (H) | W | 2-1 |
| 2017/18 | Man City | Brighton (A) | W | 2-0 |
| 2018/19 | Man City | Arsenal (A) | W | 2-0 |
| 2019/20 | Liverpool | Norwich (H) | W | 4-1 |
| 2020/21* | Man City | Wolves (A) | W | 3-1 |
| 2021/22 | Man City | Spurs (A) | L | 1-0 |
* Man City's opening match of the 2020/21 season was postponed. The Wolves match listed was in MW2.