Jose Mourinho expects both Zlatan Ibrahimovic (illness) and Marcos Rojo (muscular) to be available.
Eric Bailly is definitely out for Manchester United due to his involvement at the Africa Cup of Nations, which also rules Liverpool's top scorer Sadio Mane out of contention.
For Liverpool Philippe Coutinho (ankle), Jordan Henderson (heel) and Joel Matip (ankle) all trained on Thursday to put themselves in contention for Sunday's match
Did you know?
This will be the 50th Premier League meeting between Manchester United and Liverpool; United have won 27 of the previous 49 (D9 L13).
Only Steven Gerrard (8) has scored more goals in this Premier League fixture than Wayne Rooney, who could become the 21st player to reach 450 career PL appearances should he play in this match.
Juan Mata has had a hand in five goals in his last four PL appearances against Liverpool, scoring three and assisting two.
Adam Lallana has been involved in 14 Premier League goals this season (seven goals, seven assists); more than any other English player.
What the managers say
Jose Mourinho: "We don’t just have the good performances, we have the happiness of the good results. It's one more big match - let's enjoy it."
See: Mourinho update on Ibrahimovic and Rojo
Jurgen Klopp: “We are excited about the opportunity to go there and show our best."
See: Klopp excited about Old Trafford trip | Klopp's fitness update