Prior to Matchweek 21, check out a key statistic for each fixture, including a landmark for AFC Bournemouth's Artur Boruc and a potential double for Chelsea.
14 January
Spurs v West Brom
Tottenham Hotspur are unbeaten in the PL at home this season (W8 D2 L0); their longest run of that kind since 2000/01 (13 matches)
Burnley v Southampton
Southampton have lost the most points when leading in the top flight this season (14), but Burnley are the only side yet to gain a point when trailing
Hull v AFC Bournemouth
Artur Boruc is set to become the fourth Polish player to reach 100 PL appearances, after Wojciech Szczesny, Jerzy Dudek and Lukasz Fabianski
Sunderland v Stoke
The Black Cats are unbeaten in their last 14 home league matches against Stoke (W9 D5)
Swansea v Arsenal
Alexis Sanchez has been directly involved in 30 goals in his last 31 league outings (20 goals, 10 assists)
Watford v Middlesbrough
Only Spurs (14), Chelsea (15) and Man Utd (19) have conceded fewer goals in the PL this season than Boro (22)
West Ham v Crystal Palace
Manuel Lanzini has scored in each of his three PL matches against Palace. Six of his nine PL goals have come in London derbies
Leicester v Chelsea
Chelsea can beat the champions twice in one season for the first time since doing the double over Man Utd in 2009/10
15 January
Everton v Man City
Maarten Stekelenburg saved two penalties in Everton's 1-1 draw v Man City in October - the eighth occasion a goalkeeper had done so in one PL match
Man Utd v Liverpool
Only Steven Gerrard (8) has scored more goals in this PL fixture than Wayne Rooney (6 - level with Robbie Fowler)