Sergio Aguero will be aiming to continue the second-best goal ratio against London teams in the Premier League era when Manchester City visit Arsenal on Sunday.
Elsewhere, Jurgen Klopp eyes a record-breaking Merseyside derby treble, while Craig Shakespeare could join an exclusive club of PL managers should Leicester City beat Stoke City .
(All kick-offs are 3pm BST unless stated otherwise)
Saturday 1 April
Liverpool v Everton, 12.30pm
Jurgen Klopp could become the first Liverpool manager to win his first three PL Merseyside derbies
Burnley v Spurs
Spurs have lost only one of five previous PL matches against Burnley (W3 D1 L1)
Chelsea v Crystal Palace
Christian Benteke has scored in four different PL matches v Chelsea; against no side has he netted on more occasions
Hull City v West Ham
West Ham have conceded the most goals in the first 15 minutes of matches this season (8). Hull have conceded the most In the last 15 minutes (20)
Leicester v Stoke City
Craig Shakespeare could become the fifth manager to win his first four PL matches, after Pep Guardiola, Jose Mourinho, Guus Hiddink and Carlo Ancelotti
Man Utd v West Brom
West Brom have outrun their opponents in a PL-high 93% of their matches this season (27/29), including the last 19 in a row
Watford v Sunderland
Jermain Defoe has scored against 35 different PL teams but has not netted in four appearances against Watford
Southampton v AFC Bournemouth, 5.30pm
Joshua King has eight goals and one assist in his last eight PL appearances
Sunday 2 April
Swansea v Middlesbrough, 1.30pm
There have been a PL-high 99 goals scored in matches involving Swansea this season, while Boro's matches have had the fewest (53)
Arsenal v Man City, 4pm
Only Thierry Henry (0.73) has a better goals-per-match record v PL sides from London than Sergio Aguero (0.70, minimum 15 matches)
