West Bromwich Albion head coach Tony Pulis says "potentially we could have a full squad, potentially we could have a couple missing," but hopes Matt Phillips will be fit to start.
Southampton midfielder Steven Davis (ankle) is a doubt and Oriol Romeu serves the first of a two-match suspension.
Claude Puel is unsure if striker Manolo Gabbiadini can return from a groin injury.
Did you know?
West Bromwich Albion have failed to score in five of their last seven Premier League matches against Southampton.
Southampton have only once before lost both home and away to the Baggies in the same PL season (2012/13).
West Brom have won eight and lost two of their last 10 Premier League matches at The Hawthorns.
Nathan Redmond has scored six Premier League goals this season; his joint-best return in a top-flight season.
What the managers say
Tony Pulis: "Southampton are a fantastic model for the Premier League. They bring lots of players through and recruitment has been brilliant."
See: Pulis on Phillips fitness
Claude Puel: "West Brom are a strong team with good organisation, discipline and structure. It’s always difficult to play against this side."