Here's what to look out for over the next week, with two more fixtures remaining in Matchweek 7, eight clubs playing in Europe, and another big weekend of Premier League action ahead, concluding with the huge showdown between Arsenal and Manchester City.
Monday
Mauricio Pochettino will aim to end a run of three winless matches when his Chelsea side make the short trip to west London rivals Fulham.
The Cottagers are unbeaten in their last two contests, keeping clean sheets in both, and a victory would move them into the top half.
Arsenal manager Mikel Arteta and Manchester United boss Erik ten Hag will hold their respective press conferences ahead of Tuesday's UEFA Champions League matches.
Tuesday
In the final fixture of Matchweek 7, Luton Town will be looking to build on their first ever Premier League victory when they entertain Burnley at Kenilworth Road.
Rob Edwards' side claimed a hard-fought 2-1 win at Everton on Saturday, while the Clarets will be seeking their first victory of the season.
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In the Champions League, Arsenal enjoyed an impressive return to the competition when they brushed aside PSV Eindhoven 4-0 in the opening round, and they will be hopeful of turning on the style once more when they travel to Ligue 1 side Lens.
Man Utd were beaten 4-3 at Bayern Munich in their first Champions League match and will look for a better outcome when they welcome Turkish champions Galatasaray to Old Trafford.
Meanwhile, Pep Guardiola and Eddie Howe will hold their press conferences ahead of Man City and Newcastle United's matches in the same competition.
Wednesday
Newcastle play their first Champions League match at St James' Park since 2003 when they host French giants Paris Saint-Germain, while Man City travel to Germany to take on RB Leipzig at 20:00 BST.
David Moyes, Roberto De Zerbi and Jurgen Klopp will hold press conferences ahead of their UEFA Europa League group-stage matches, while Aston Villa manager Unai Emery will also speak to the media ahead of his team's UEFA Europa Conference League meeting with Zrinjski, who play in Bosnia and Herzegovina.
Thursday
West Ham United travel to Germany to face Bundesliga side Freiburg, while Brighton and Hove Albion will be in France to take on Marseille, both matches starting at 17:45 BST.
Liverpool are back at Anfield as they take on Belgian side Union Saint-Gilloise, with Reds midfielder Alexis Mac Allister potentially facing his brother Kevin, who plays as a defender for the visitors.
In the Europa Conference League, Villa welcome Zrinjski to Villa Park.
Several managers will hold press conferences as they provide updates ahead of the weekend's Premier League fixtures.
Friday
The remaining Premier League managers will hold their press conferences, providing the latest team news.
Saturday
Matchweek 8 begins with Tottenham Hotspur's lunchtime trip to Luton at 12:30 BST, with Spurs aiming to go top of the table for a day at least. The Fantasy Premier League deadline comes 90 minutes beforehand, at 11:00 BST.
Following this, there will be four 15:00 BST kick-offs, before Crystal Palace take on Nottingham Forest at 17:30 BST.
Sunday
Several sides taking part in midweek European action play on Sunday as Brighton host Liverpool in a top-six duel, West Ham entertain a Newcastle side who are a point behind them, and Villa make the short trip to take on Wolverhampton Wanderers.
Finally, the standout fixture of the weekend takes place, as last season's runners-up Arsenal face champions Man City at Emirates Stadium.