Here's what to look out for over the next seven days, with pivotal international matches and then the Premier League's return, including a busy Saturday featuring SEVEN fixtures.
Euro 2024 qualifiers
There are key matches to be played as nations seek to qualify for the 2024 European Championship by earning a top-two finish in their respective groups.
On Monday, West Ham United midfielder Tomas Soucek will be hoping he and his Czech Republic team-mates can get the win that would guarantee a place in next summer's finals in Germany when they take on Moldova in Group E.
In the final matches of Group D, Manchester City defender Josko Gvardiol and his second-placed Croatia side host Armenia lying two points ahead of Wales, who entertain Turkey.
2026 World Cup qualifiers
Gambia host Ivory Coast on Monday, which could see Nottingham Forest trio Serge Aurier, Willy Boly, Ibrahim Sangare, plus Brighton & Hove Albion's Simon Adingra and AFC Bournemouth midfielder Hamed Traore all feature for the visitors. All except Traore could face each other once again on Saturday, when Forest entertain Brighton.
In the CONMEBOL World Cup qualifiers, Liverpool's Luis Diaz and Darwin Nunez could be in action on Tuesday, as Colombia visit Paraguay and Uruguay welcome Bolivia.
Argentina then travel to Brazil in a titanic duel, where Arsenal pair Gabriel Martinelli and Gabriel, Newcastle United's Bruno Guimaraes and Liverpool goalkeeper Alisson Becker could face Man City star Julian Alvarez, Chelsea's Enzo Fernandez, Tottenham Hotspur defender Cristian Romero and Aston Villa's Emiliano Martinez.
Press conferences
Premier League clubs' managers will face the media on Thursday and Friday to provide updates on their players' fitness and availability after their return from international duty.
Fantasy Premier League returns
Managers in Fantasy Premier League will have until 11:00 GMT on Saturday to make transfers and finalise their teams.
Premier League action resumes
There are seven fixtures on Saturday, starting with the huge showdown between first and second as champions Man City host Liverpool, with the Reds seeking their first Premier League win at the Etihad Stadium since November 2015.
There will then be five 15:00 GMT kick-offs, including Newcastle v Chelsea, before Arsenal visit Brentford in a London derby at 17:30 GMT.
On Sunday, Ange Postecoglou's fourth-placed Spurs side face fifth-placed Villa at 14:00 GMT. Spurs are looking for their first win in three matches, while Villa have lost only one of their last eight league matches.
Then, at 16:30 GMT, Everton take on Manchester United at Goodison Park. The Toffees are unbeaten in their last three league matches, winning two of those. But United also head to Merseyside in good form, having won four of their last five league matches.
Matchweek 13 concludes on Monday night when Fulham host Wolverhampton Wanderers.