Tottenham Hotspur will make history if they end their 128-year stay at White Hart Lane with victory over Manchester United on Sunday.
Spurs need to avoid defeat to go unbeaten at home in a Premier League season for the first time, and if they defeat Jose Mourinho's side they will match their club record of 14 consecutive victories at their home ground.
Elsewhere, Gylfi Sigurdsson aims to set a Swansea City record, Chelsea can claim their fifth Premier League title and Liverpool could be unbeaten in London for the first time in a PL season. For more stats, see below.
Friday 12 May
Everton v Watford
If Everton win they will have gained more points at home in 2016/17 (43) than in any previous PL campaign
West Bromwich Albion v Chelsea
Chelsea will claim their fifth Premier League title if they win this fixture. Only Manchester United (13) have won more
Saturday 13 May
Manchester City v Leicester City
Leicester are aiming to win three successive league matches against Man City for the first time since March 1967
AFC Bournemouth v Burnley
The Clarets are aiming to win successive PL away matches for only the second time
Middlesbrough v Southampton
Winning 1-0 in the reverse fixture, Southampton are looking to do a top-flight double over their opponents for the first time since 1996/97
Sunderland v Swansea City
If Gylfi Sigurdsson scores he will become the first Swansea player to reach double figures for both goals (nine) and assists (12) in a PL season
Stoke City v Arsenal
Peter Crouch has scored eight Premier League goals against Arsenal, his joint-highest total against one team
Sunday 14 May
Crystal Palace v Hull City
Palace have lost all three of their previous home matches this term against opposition who started the day in the relegation zone
West Ham United v Liverpool
If they avoid defeat Liverpool will go unbeaten in London in a Premier League season for the first time (currently W3 D1)
Tottenham Hotspur v Manchester United
In their final match at White Hart Lane, Spurs can go unbeaten in a league season for the first time since 1964/65 and match their club record run of 14 straight home wins set in 1987