Spurs need to avoid defeat to go unbeaten at home in a Premier League season for the first time, and if they defeat Jose Mourinho's side they will match their club record of 14 consecutive victories at their home ground.
Elsewhere, Gylfi Sigurdsson aims to set a Swansea City record, Chelsea can claim their fifth Premier League title and Liverpool could be unbeaten in London for the first time in a PL season. For more stats, see below.
In their final match at White Hart Lane, Spurs can go unbeaten in a league season for the first time since 1964/65 and match their club record run of 14 straight home wins set in 1987