Here's what to look out for over the next seven days, with clubs in European action which will be followed by the draw for the respective competitions on Friday, several Premier League fixtures and the FA Cup quarter-final ties which includes a huge showdown between Manchester United and Liverpool.
Monday
Matchweek 28 continues on Monday night as Chelsea face Newcastle United at Stamford Bridge.
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Chelsea have not lost at home to Newcastle since May 2012, winning 20 of their 28 encounters, while they have not been beaten at Stamford Bridge in the month of March since a 4-2 defeat to Sunderland back in 2001.
Mikel Arteta will provide the latest team news updates in his press conference ahead of Arsenal’s UEFA Champions League (UCL) round-of-16 second-leg tie at home to Porto.
Tuesday
Arsenal host Porto at Emirates Stadium aiming to overturn a 1-0 first-leg loss to qualify for the quarter-finals. The match begins at 20:00 GMT.
AFC Bournemouth head coach Andoni Iraola and Luton Town boss Rob Edwards will hold press conferences ahead of Wednesday’s fixture.
Wednesday
The final encounter of Matchweek 28 is between Bournemouth and Luton, who both scored in second-half stoppage time in their last fixture against Sheffield United and Crystal Palace respectively to earn a point.
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Elsewhere, Roberto De Zerbi, Jurgen Klopp, David Moyes and Unai Emery will hold press conferences ahead of European matches for Brighton & Hove Albion, Liverpool, West Ham United and Aston Villa on Thursday.
Thursday
Brighton welcome Italian giants Roma in the UEFA Europa League (UEL) round of 16 second leg and have a huge task at hand to progress, having been beaten 4-0 in the reverse fixture.
Liverpool host Sparta Prague and should be confident of going through after they secured an emphatic 5-1 success in the Czech Republic.
West Ham face German side Freiburg at London Stadium. The Hammers suffered a narrow 1-0 loss in the first leg.
In the UEFA Europa Conference League (UECL), Villa are at home to Ajax for their second leg, with the tie still level after a goalless draw in their last meeting.
Elsewhere, several managers will be holding their press conferences as they provide the latest injury updates ahead of the weekend's Premier League fixtures.
Friday
The draws for the quarter-finals of the Champions League, Europa League and Europa Conference League take place. The Champions League draw starts at 11:00 GMT while the remaining clubs in the other two competitions will learn their opponents at 12:00 and 13:00 GMT respectively.
More managers will address the media ahead of the weekend's fixtures.
Saturday
The Fantasy Premier League deadline for Blank Gameweek 29 is at 13:30 GMT.
There are three matches taking place, with two kicking off at 15:00 GMT and concluding at 17:30 GMT with a London derby between Fulham and Tottenham Hotspur at Craven Cottage.
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In the FA Cup quarter-finals, there are two matches involving Premier League clubs, with Wolverhampton Wanderers facing Coventry City at 12:15 GMT, followed by Manchester City at home to Newcastle which begins at 17:30 GMT.
FA Cup quarter-finals
12:15 Wolves v Coventry`
17:30 Man City v Newcastle
Sunday
There is one Premier League fixture taking place, with West Ham welcoming Villa.
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There are two more FA Cup quarter-final ties, as Chelsea face Leicester City in a repeat of the 2021 final and this is followed by a mouthwatering encounter between Man Utd and Liverpool at Old Trafford, kicking off at 15:30 GMT.
FA Cup quarter-finals
12:45 Chelsea v Leicester
15:30 Man Utd v Liverpool