Here's what to look out for over the next seven days, with 16 Premier League fixtures that will have a big impact in the title race, who will qualify for European football next season and the battle to avoid relegation.
Monday
Mikel Arteta and Mauricio Pochettino will provide the latest team news updates in their press conferences ahead of Arsenal’s home encounter with Chelsea on Tuesday.
Tuesday
Matchweek 34 continues on Tuesday night as the Gunners host Chelsea at Emirates Stadium looking to record a sixth win in eight Premier League meetings against their London rivals.
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Elsewhere, Liverpool boss Jurgen Klopp will be speaking to the media ahead of his last-ever Merseyside derby against Everton the following day, while several other managers will also hold press conferences prior to their Premier League matches on Wednesday evening.
Wednesday
In addition to Liverpool's trip to Goodison Park to face Sean Dyche's Everton, there are three other fixtures to look forward to, starting at Molineux where Wolverhampton Wanderers host AFC Bournemouth, while European hopefuls Newcastle United and Manchester United are in action, at Crystal Palace and home to Sheffield United respectively.
There will be updates from both Roberto De Zerbi and Pep Guardiola as they finalise preparations for Brighton & Hove Albion's home match against Manchester City on Thursday.
Thursday
Matchweek 34 concludes as Man City switch their attention back to the title race following their FA Cup semi-final exploits at the weekend.
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Brighton have lost 11 of their 13 Premier League meetings with City, although they did hold them to a 1-1 draw in the corresponding fixture last season, and recorded their only win against City across this period at Amex Stadium in 2021, a 3-2 victory.
Elsewhere, several managers will be holding their press conferences as they provide the latest injury updates ahead of the weekend's Premier League fixtures.
Friday
All eyes will be on the day's media briefings as the remaining managers share their thoughts and team news ahead of a full weekend's Premier League programme.
Saturday
The Fantasy Premier League deadline for Double Gameweek 35 is at 11:00 BST.
There are seven matches taking place, starting at London Stadium, where West Ham United host Liverpool at 12:30 BST, followed by four fixtures kicking off at 15:00 BST, including a Lancashire derby between Man Utd and Burnley at Old Trafford.
The drama continues in a huge relegation battle at Goodison Park, where Everton face Brentford, with a mouthwatering contest between Aston Villa and Chelsea at Villa Park bringing the day's action to a close at 20:00 BST.
Sunday
Expect fireworks at Tottenham Hotspur Stadium in Sunday's standout fixture as the huge north London derby between Tottenham Hotspur and Arsenal gets under way at 14:00 BST in a match that has huge implications at the top of the table.
The two teams produced a thrilling 2-2 draw at Emirates Stadium in the reverse fixture, and with Man City's match at Nottingham Forest following on at 16:30 BST, Arsenal need to keep the pressure on their title rivals while Spurs must win to stay in the hunt for fourth place.