Paul Pogba, Zlatan Ibrahimovic and Marcos Rojo have recovered from injuries and could feature for Manchester United.
Defender Phil Jones, however, is likely to miss the match because of a thigh injury.
Newcastle United's Christian Atsu (thigh) and Jamaal Lascelles (ankle) join Paul Dummett and Mikel Merino in being ruled out.
Goalkeeper Rob Elliot and defender Ciaran Clark are available.
Did you know?
Manchester United have won 22 and lost only one of their last 32 league matches against Newcastle United at Old Trafford (W22 D9 L1).
Man Utd are unbeaten in 22 PL matches at Old Trafford (W12 D10 L0), winning the last six in a row without conceding. They last won seven consecutive home PL matches without conceding in March 2010.
Rafa Benitez could become the first manager in PL history to win at Old Trafford with three different away clubs, having won there with Chelsea and Liverpool previously.
Romelu Lukaku has been directly involved in nine goals in eight PL appearances against Newcastle (five goals, four assists).
What the managers say
Jose Mourinho: "I know the way Newcastle play, I know the way Benitez prepares his team, I know that it's going to be difficult but we have to try to get back to the points that we need."
See: Mourinho on Zlatan and Pogba
Rafael Benitez: "They are a good team and they have very good players, so we will have to do almost everything right, perfect, to make sure we can get three points."
See: Benitez's Old Trafford gameplan
Referee: Craig Pawson
Assistants: Lee Betts, Constantine Hatzidakis
Fourth official: Paul Tierney