Manchester City head coach Pep Guardiola says he has no new injury concerns ahead of Wednesday's match.
Southampton only have long-term absentee Matt Targett ruled out, as Oriol Romeu returns from suspension.
Did you know?
Manchester City have the best-ever points total by a team after 13 matches of a Premier League season (37 points).
Manchester City have scored 24 PL goals at home this season, double the number they’d scored after six home matches of 2016/17.
Southampton striker Charlie Austin has been directly involved in eight goals in his last 11 PL starts (seven goals, one assist).
Sergio Aguero has three goals and two assists in his last six PL matches versus Southampton and has scored in six successive PL appearances overall (eight goals).
What the managers say
Pep Guardiola: "We have made a good recovery. We are preparing for a mentally tough game against Southampton."
See: Guardiola looking forward to meeting friend Pellegrino
Mauricio Pellegrino: "It's incredible how Man City can sustain their performance in every single game."
See: Pellegrino previews Man City trip
Referee: Paul Tierney
Assistants: Adrian Holmes, Mick McDonough
Fourth official: Bobby Madley
