With last season providing plenty of surprises and 2016/17 just days away, we look at some of the biggest upsets of past opening weekends.
Wigan Athletic 0-4 Blackpool
Making their return to the top flight for the first time since 1971, Ian Holloway's Blackpool entered 2010/11 as one of the Premier League's biggest underdogs.
The Tangerines had been promoted via the Championship play-offs, having edged into sixth at the end of the campaign.
Wigan were starting their sixth season in the Premier League but the difference in experience had little effect as the home side found themselves quickly on the ropes.
Gary Taylor-Fletcher's opener and a brace from Marlon Harewood put Blackpool three goals up in the first half and Alex Baptiste added gloss to the scoreline after the break.
For a couple of hours Blackpool were top of the table until Chelsea beat West Bromwich Albion 6-0 in the day's late kick-off.
The Tangerines' dream was maintained until a poor run of form in the second half of the season meant that Holloway's side were relegated on the final day of the season with a 4-2 defeat at Manchester United.
Wigan narrowly avoided following Blackpool, winning their last two matches against West Ham United and Stoke City.