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Sam Allardyce's stint as England manager got under way with a 1-0 triumph over Slovakia as Adam Lallana (£7.1million) netted the Three Lions' injury-time winner.
Lallana successfully translated his early domestic form to the interanational stage - he has produced more attempts inside the penalty area (eight) than any other midfielder over the opening three Gameweeks of the season.
Elsewhere in the England camp, there is contrasting news on a trio of popular Fantasy Premier League defenders.
John Stones (£5.0m) is available for selection once again. The Manchester City summer signing, who resides in more squads (31.8%) than any defensive option, recovered from an eye problem to start on Sunday evening.
Kyle Walker (£5.6m, 21.3% ownership) shook off the illness that forced him off during the Gameweek 3 draw against Liverpool and played the full 90 minutes for Allardyce's side.
Residing in 25.8% of FPL squads, Luke Shaw (£5.6m) withdrew from international duties with a minor muscle problem, though is expected to be fit for Saturday's Manchester derby.
Meanwhile, Lallana's Anfield team-mate Georginio Wijnaldum (£7.9m) netted in Holland's 2-1 home loss to Greece and Sadio Mane (£8.9m) was withdrawn during Senegal's 2-0 win over Namibia at the weekend. Reports have since suggested that this was purely a precaution but his managers will be looking for updates from Liverpool.
Robert Snodgrass (£5.6m) recovered from a calf complaint to play a starring role in Scotland's 5-1 win over Malta.
Forced off through injury in Gameweek 3, the fit-again playmaker - who netted the Tigers' opening day winner against champions Leicester City - maintained his fine recent form by bagging a hat-trick on Sunday evening.
Having managed only one assist on the domestic scene, Manchester City's David Silva (£8.9m) stepped up his output by scoring both goals in Spain's 2-0 win over Belgium.
Diego Costa (£9.7m) emerged from the bench to supply an assist and remains in fine form. The Chelsea man is the second most transferred-in forward in the Gameweek and has produced attacking returns in each of the opening three fixtures.
Tottenham Hotspur's Christian Eriksen (£8.4m) shrugged off his sluggish start to the domestic campaign by scoring the only goal in Denmark's weekend win over Armenia.
Another midfield big-hitter, Paul Pogba (£8.5m), provided a pair of assists as France defeated Italy 3-1.
Manchester United team-mate Anthony Martial (£9.5m) fired the opener and was joined on the scoresheet by Arsenal striker Olivier Giroud (£9.0m).
The latter now looks in line for a first start of the Premier League season at home to Southampton next weekend after improving his match sharpness over the break.
Fears have eased over Laurent Koscielny (£6.0m), who was withdrawn as a precaution for Les Bleus. The Arsenal defender suffered a slight back problem but has since returned to full training and is available for Tuesday's encounter with Belarus.
West Ham United were also afforded some welcome news after Dimitri Payet (£9.4m) proved his fitness with a second-half outing off the bench.
Sold by over 465,000 FPL managers after managing only 24 minutes of top-flight action so far, Payet now prepares for four home fixtures in the next six Gameweeks as the Hammers host Watford, Southampton, Middlesbrough and Sunderland.
