The Under-18 Premier League season will kick off with a London derby between Arsenal and Chelsea on Saturday 10 August.
Arsenal won the U18 Premier League South last season before losing 5-2 to Derby County, the winners of the North Division, in the national final.
And their bid to go one step further will begin with a home match against the U18 PL champions in 2016/17 and 2017/18 in a full round of fixtures on the opening day.
Derby, who also qualified for the UEFA Youth League by winning the title, will start their defence with a trip to Everton.
Other notable Matchweek 1 fixtures include Tottenham Hotspur's trip to Fulham in the South Division, while Liverpool, who finished second in the North Division, visit Blackburn Rovers.
See: Full 2019/20 U18 Premier League fixtures
Sync the U18 fixtures to your mobile device by using the Premier League's digital calendar.
Matchweek 1 fixtures
Saturday, 10 August
North Division
11:00 Blackburn v Liverpool
11:00 Newcastle v Middlesbrough
11:00 Stoke v Wolves
11:30 Everton v Derby
11:30 West Brom v Man City
12:30 Man Utd v Sunderland
South Division
11:00 Arsenal v Chelsea
11:00 Fulham v Spurs
11:00 West Ham v Swansea
12:00 Brighton v Reading
12:00 Leicester v Norwich
12:30 Southampton v Aston Villa