A win for 16th-placed Everton would boost their prospects of avoiding relegation as they lie two points above Burnley, in 17th, and Leeds United, in 18th. The Blues have played the same number of matches as Burnley but one fewer than Leeds.
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Everton can go four league matches unbeaten for the first time since their opening four fixtures of the season under Rafael Benitez.
The Toffees have won their last four home matches against Brentford in all competitions, including a 4-1 victory in the FA Cup this season.
Brentford won the reverse fixture against Everton 1-0 in November; their only league double against the Toffees came in the first ever campaign in which the sides met, back in 1935/36.
The Bees have had 15 different goalscorers in the Premier League this season – excluding 1992/93, the only team to have more in their debut campaign in the competition were Bolton Wanderers in 1995/96 (16).
Match officials
Referee: Michael Oliver. Assistants: Stuart Burt, Scott Ledger. Fourth official: Andy Madley. VAR: Darren England. Assistant VAR: Sian Massey-Ellis.