Manchester City have been dealt a blow in their quest for a third consecutive Premier League title with the news that Phil Foden is set for a spell on the sidelines.
"Manchester City can confirm Phil Foden has left the England squad after undergoing surgery in London for acute appendicitis," a club statement said.
"He will not be fit for this weekend’s Premier League game at home to Liverpool and it is unclear at this stage how long he will be unavailable for."
It is bad news for Man City, who are eight points behind leaders Arsenal but can put pressure on their title rivals by beating Liverpool in Saturday's early kick-off, before Arsenal face Leeds.
Foden had been in good form, producing two goals and an assist in his last three Premier League appearances.
Following their meeting with Liverpool, City travel to Southampton before hosting Leicester City.
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Pep Guardiola's side also face Bayern Munich in the UEFA Champions League quarter-finals next month, with the first leg taking place at the Etihad Stadium on 11 April, before heading to Germany for the second leg on 19 April.
They then have an FA Cup semi-final against Sheffield United before a massive title head-to-head with Arsenal on Wednesday 26 April.
Erling Haaland is also an injury concern for City ahead of the visit from Liverpool, after the Premier League's top scorer withdrew from the Norway squad due to a groin injury.