Chelsea face an uphill battle to reach the UEFA Champions League semi-finals after suffering a 2-0 defeat against Real Madrid at the Bernabeu Stadium.
Frank Lampard, taking charge of only his second match after returning as Chelsea manager last week, picked Thiago Silva and N'Golo Kante in his starting XI, the latter making only his second full appearance since August.
The current Champions League holders took the lead on 21 minutes, as Karim Benzema finished from close range beyond Kepa Arrizabalaga.
Real had won 29 of their previous 30 Champions League matches when scoring first under Carlo Ancelotti, and fortune favoured the former Chelsea manager when Ben Chilwell was shown a straight red card on 59 minutes for a foul on Rodrygo.
Vinicius Junior set up substitute Marco Asensio to add a second for Real with 14 minutes remaining, as Chelsea suffered only their second defeat in eight matches against the Spanish giants in European competition.
Chelsea return to Premier League action against Brighton & Hove Albion on Saturday in Lampard's first home match since his return to Stamford Bridge.
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