Manchester United's Luke Shaw will miss "a number of weeks" after sustaining a muscle injury.
Man Utd are still assessing the 28-year-old, but Shaw will not be available for their forthcoming matches, starting with the home match against Nottingham Forest on Saturday.
Shaw's injury is another setback for the Red Devils, who have Mason Mount unavailable after the midfielder picked up an injury the club described as a "small complaint" during their 2-0 loss at Tottenham Hotspur last Saturday.
Harry Maguire also missed the defeat at Spurs due to a knock, while fellow defender Tyrell Malacia has been sidelined for a number of weeks.
That leaves Diogo Dalot as an option at left-back, having previously filled that role.
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Shaw's injury is a blow for a number of Fantasy Premier League managers with the left-back being owned by over 22 per cent.
See: Best replacements for injured Shaw in Fantasy
Man Utd will look to return to winning ways against Forest at Old Trafford, having beaten Wolverhampton Wanderers 1-0 in Matchweek 1 before that defeat at Spurs to last time out.