Here's what to look out for over the next seven days, with the EFL Cup throwing up five midweek duels between Premier League clubs, followed by a busy Saturday featuring EIGHT fixtures.
Monday
Early team news will start to filter out as EFL Cup holders Manchester United and four other Premier League clubs turn their attention to Tuesday night's third-round ties.
Mason Mount and Harry Maguire have both been spotted at United's Carrington training ground ahead of the Red Devils' home match against Crystal Palace, while press conferences will also bring the latest news from Burnley, Luton Town and Wolverhampton Wanderers.
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Tuesday
Press conferences will continue to bring the latest team news and managers' thoughts in preparation for more midweek action.
Pep Guardiola has already confirmed Jack Grealish will play some part for Manchester City as they face a Newcastle United team buoyant following their 8-0 win at Sheffield United on Sunday.
See: Newcastle join list of biggest wins in Premier League history
Man Utd host Palace at 20:00 BST, four days before the teams meet again in the Premier League. Luton visit League One side Exeter City, while Burnley travel to take on League Two outfit Salford City.
Gary O'Neil's Wolves have a tricky test at Ipswich Town, who are second in the Championship table with seven wins from their eight league matches this season.
Tuesday's EFL Cup ties (19:45 BST unless otherwise stated)
Exeter v Luton
Ipswich v Wolves
Salford v Burnley
20:00 Man Utd v Crystal Palace
The Under-21 teams from Chelsea, Man Utd, Man City and Everton are also in EFL Trophy action. The competition offers an opportunity for academy players to gain valuable experience on their career pathway. Indeed, Gabriel Martinelli, Declan Rice and Bukayo Saka have all played in the competition.
All four clubs face away ties. Chelsea visit Northampton Town, Man City face Barnsley and Everton play Burton, while Man Utd lock horns with Trophy holders Bolton Wanderers.
Wednesday
A further 12 Premier League clubs will be looking to book their place in the fourth round of the EFL Cup, with eight of those being engaged in duels with top-flight rivals.
Aston Villa face Everton, Brentford host Arsenal, Chelsea play Brighton & Hove Albion and Newcastle will look for revenge against Man City, having already lost 1-0 to them this season.
AFC Bournemouth, Fulham and Liverpool each face Championship sides - Stoke City, Norwich City and Leicester City respectively.
West Ham make the trip to giant-killers Lincoln City, who knocked out Sheffield United in the second round on penalties.
The draw for the fourth round will be held following the conclusion of the Newcastle v Man City tie.
Wednesday's EFL Cup ties (19:45 BST unless otherwise stated)
Aston Villa v Everton
AFC Bournemouth v Stoke
Brentford v Arsenal
Chelsea v Brighton
Fulham v Norwich
Lincoln v West Ham
Liverpool v Leicester
20:00 Newcastle v Man City
Thursday
Some clubs' managers will be holding their press conferences ahead of a full weekend of Premier League fixtures, providing updates on the latest team news.
Friday
The remaining Premier League managers will face the media, providing injury and fitness updates.
Saturday
Matchweek 7 of the Premier League starts with the 12:30 BST kick off between Villa and Brighton, so Fantasy Premier League managers should look out for an earlier deadline of 11:00 BST.
There will be eight matches on Saturday, concluding with a mouthwatering tussle between unbeaten top-four rivals Tottenham Hotspur and Liverpool at 17:30 BST.
Sunday
There's only one match in the calendar, between Nottingham Forest and Brentford, who are separated by one place and a single point in the table.