Premier League clubs will be without key players over the next month as African and Asian players look to bring glory to their respective countries.
The Africa Cup of Nations (AFCON) runs from January 13 to 11 February in Ivory Coast, while the Asian Cup, in Qatar, will take place from 12 January to 10 February.
In total, 39 Premier League players will be away representing their countries.
Senegal are the African nation featuring the most Premier League players with six, including Nottingham Forest's Moussa Niakhate. The defender is one of six Forest players taking part in AFCON, more than any other club in the Premier League.
In comparison, Manchester City, Burnley and Newcastle United each have no players featuring in either tournament.
Here are all the Premier League players heading off to AFCON and the Asian Cup and the matches they could miss.
Arsenal
Mohamed Elneny (Egypt), Takehiro Tomiyasu (Japan)
Fixtures: Liverpool (FA Cup), Crystal Palace (H), Nott'm Forest (A), Liverpool (H), West Ham (A)
Aston Villa
Bertrand Traore (Burkina Faso)
Fixtures: Middlesbrough (FA Cup), Everton (A), Newcastle (H), Sheff Utd (A), Man Utd (H)
AFC Bournemouth
Dango Ouattara (Burkina Faso), Antoine Semenyo (Ghana)
Fixtures: QPR (FA Cup), Liverpool (H), West Ham (A), Nott'm Forest (H), Fulham (A)
Brentford
Saman Ghoddos (Iran), Kim Ji-soo (South Korea), Frank Onyeka (Nigeria), Yoane Wissa (DR Congo)
Fixtures: Nott'm Forest (H), Spurs (A), Man City (H), Wolves (A)
Brighton & Hove Albion
Simon Adingra (Ivory Coast), Kaoru Mitoma (Japan)
Fixtures: Stoke (FA Cup), Wolves (H), Luton (A), Crystal Palace (H), Spurs (A)
Burnley
None
Fixtures: Luton (H), Man City (A), Fulham (H), Liverpool (A)
Chelsea
Nicolas Jackson (Senegal)
Fixtures: Preston (FA Cup), Middlesbrough (EFL Cup), Fulham (H), Middlesbrough (EFL Cup), Liverpool (A), Wolves (H), Crystal Palace (A)
Crystal Palace
Jordan Ayew (Ghana)
Fixtures: Arsenal (A), Sheff Utd (H), Brighton (A), Chelsea (H)
Everton
Idrissa Gueye (Senegal)
Fixtures: Aston Villa (H), Fulham (A), Spurs (H), Man City (A)
Fulham
Calvin Bassey (Nigeria), Alex Iwobi (Nigeria), Fode Ballo-Toure (Senegal)
Fixtures: Liverpool (EFL Cup), Chelsea (A), Liverpool (EFL Cup), Everton (H), Burnley (A), Bournemouth (H)
Liverpool
Wataru Endo (Japan), Mohamed Salah (Egypt)
Fixtures: Arsenal (FA Cup), Fulham (EFL Cup), Bournemouth (A), Fulham (EFL Cup), Chelsea (H), Arsenal (A), Burnley (H)
Luton Town
Issa Kabore (Burkina Faso)
Fixtures: Bolton (FA Cup), Burnley (A), Brighton (H), Newcastle (A), Sheff Utd (H)
Manchester City
None
Fixtures: Huddersfield (FA Cup), Newcastle (A), Burnley (H), Brentford (A), Everton (H)
Manchester United
Sofyan Amrabat (Morocco), Andre Onana (Cameroon)
Fixtures: Wigan (FA Cup), Spurs (H), Wolves (A), West Ham (H), Aston Villa (A)
Newcastle
None
Fixtures: Man City (H), Aston Villa (A), Luton (H), Nott'm Forest (A)
Nottingham Forest
Ola Aina (Nigeria), Serge Aurier (Ivory Coast), Willy Boly (Ivory Coast), Cheikhou Kouyate (Senegal), Moussa Niakhate (Senegal), Ibrahim Sangare (Ivory Coast)
Fixtures: Blackpool (FA Cup), Brentford (A), Arsenal (H), Bournemouth (A), Newcastle (H)
Sheffield United
Yasser Larouci (Algeria), Anis Ben Slimane (Tunisia)
Fixtures: Gillingham (FA Cup), West Ham (H), Crystal Palace (A), Aston Villa (H), Luton (A)
Tottenham Hotspur
Yves Bissouma (Mali), Son Heung-min (South Korea), Pape Sarr (Senegal)
Fixtures: Man Utd (A), Brentford (H), Everton (A), Brighton (H)
West Ham United
Nayef Aguerd (Morocco), Mohammed Kudus (Ghana)
Fixtures: Bristol City (FA Cup), Sheff Utd (A), Bournemouth (H), Man Utd (A), Arsenal (H)
Wolverhampton Wanderers
Rayan Ait-Nouri (Algeria), Hwang Hee-chan (South Korea), Justin Hubner (Indonesia), Boubacar Traore (Mali)
Fixtures: Brighton (A), Man Utd (H), Chelsea (A), Brentford (H)
AFCON groups
The groups are set. ✅#TotalEnergiesAFCON2023 is now ready to kick off in January! 🇨🇮⚽️ pic.twitter.com/Xxanb9FDzp
— CAF (@CAF_Online) October 12, 2023
Asian Cup groups
The canvas is set and the time to paint the perfect picture looms!
— #AsianCup2023 (@afcasiancup) November 23, 2023
Which is the most interesting #AFCU23 Qatar 🇶🇦 group? 🤔 pic.twitter.com/lk1OIYZKZF