Liverpool and Brighton & Hove Albion topped their groups on Day 2 of the ePremier League Group Stages to qualify for the quarter-finals on Sunday 23 March.
They join Manchester City and Ipswich Town in automatic qualification for the last eight, with the champions earning a share of the £100,000 prize pool, and seats at the EA SPORTS FC Pro World Championship and eChampions League.
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Liverpool were the first club to seal their berth on Day 2, opening the action with two Merseyside derby wins over Everton.
Convincing victories for pros Leks and ManuBachoore continued through their Group C campaign, including a 10-1 demolition of Crystal Palace, as they dropped just two points to comfortably finish top.
See: All the results
Crystal Palace took second spot, followed by Brentford, Arsenal and Everton.
Brighton also booked their spot in the Grand Finals with a tense last match against Leicester, with both clubs vying for top spot in Group D.
Jayden Groden and Marley came out victorious with results of 4-0 and 3-3 respectively, as Brighton won their group for a second successive year.
They edged out Leicester by one point following four wins, two draws and two losses, in the most tightly contested group of the weekend. West Ham finished third, followed by Spurs and AFC Bournemouth.
The 16 clubs who did not qualify directly for the Quarter Finals will battle for a place on Saturday 22 March in the Knockout Stages, before the Grand Finals on Sunday 23 March.