With last season providing plenty of surprises and 2016/17 now only days away, we look at some of the biggest upsets of past opening days.
West Bromwich Albion 3-0 Liverpool
In the first competitive match of the Brendan Rodgers era at Liverpool, the Reds travelled to The Hawthorns full of optimism on the opening day of 2012/13.
Things did not go to plan for the visitors, however, as the Northern Irishman's side fell to an unexpected 3-0 loss against West Bromwich Albion - a result that would prove to be their largest margin of defeat all season.
Goals from Zoltan Gera, Peter Odemwingie and Romelu Lukaku headlined the comfortable win for Steve Clarke’s team, who could have inflicted an even heavier defeat had Shane Long converted his penalty after Daniel Agger was shown a red card.
Albion would use their opening-day platform to record an eighth-placed Premier League finish come May, one spot below Liverpool.