Miguel Almiron's first-half double helped Newcastle United beat Southampton at St James' Park, despite ending an entertaining match with just nine men.
Allan Saint-Maximin squared for debutant Joe Willock to put Newcastle ahead after 16 minutes.
Newcastle doubled their advantage on 26 minutes through Almiron's deflected low strike.
Takumi Minamino fired a high angled shot four minutes later to pull a goal back on his Southampton debut.
But Newcastle restored their two-goal lead in first-half stoppage-time after Almiron took advantage of Alex McCarthy's bad pass.
James Ward-Prowse's stunning free-kick on 48 minutes revived Saints' hopes, which were lifted further when Newcastle's Jeff Hendrick was shown a second yellow card two minutes later.
Danny Ings hit a post, but Southampton could not find an equaliser despite Newcastle losing another player when Fabian Schar went off injured after all substitutes had been used.
Newcastle sit 16th with 25 points, four behind 12th-placed Southampton having played a match more.
See: Newcastle report | Southampton report
Next fixtures
Newcastle: 15 Feb v Chelsea (A)
Southampton: 14 Feb v Wolves (H)
Match officials
Referee: Craig Pawson. Assistants: Ian Hussin, Richard West. Fourth official: John Brooks. VAR: Robert Jones. Assistant VAR: Adrian Holmes.
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