Team news
Find out the latest team news here.
Did you know?
Tottenham Hotspur's Son Heung-min has only scored more goals in all competitions against Southampton (11) than he has against Manchester City (6).
Nuno Espirito Santo can become the fifth Spurs manager/head coach to win on their Premier League debut.
Pep Guardiola is the only manager/head coach to win all opening day matches (5/5) among those to have taken charge of at least four fixtures.
Man City have won their first league match of the season in each of their last 10 top-flight campaigns since 2011/12.
Match officials
Referee: Anthony Taylor. Assistants: Gary Beswick, Adam Nunn. Fourth official: Craig Pawson. VAR: Stuart Attwell. Assistant VAR: Constantine Hatzidakis.