Southampton defender Virgil van Dijk will miss two to three months with a ankle injury and Jay Rodriguez and James Ward-Prowse are doubtful.
New signing Manolo Gabbiadini is ft and available for selection, Claude Puel has confirmed.
West Ham United have reported no new injuries apart from Sam Byram, whom Slaven Bilic is hopeful can overcome a hamstring problem.
Did you know?
Southampton have won their last two matches against West Ham; they last won three consecutively against them in April 1998.
West Ham are winless in their last seven away league matches against the Saints (D4 L3), last winning in Southampton in November 2000.
Fraser Forster has not conceded a Premier League goal against West Ham in 333 minutes of action, keeping three consecutive clean sheet in that time.
Andy Carroll has been directly involved in six goals in his last nine away PL matches (five goals, one assist).
What the managers say
Claude Puel: "Van Dijk will stay not available for many weeks, two or three months. I don’t know how many times he will stay out but it’s a problem."
See: Puel on Gabbiadini chances
Slaven Bilic: "I like the way Southampton play. They've had ups and downs and played a lot of games, and have had injuries and got new players."
