Here's what to look out for over the next seven days involving Premier League clubs.
Monday
Nottingham Forest will lock horns with Burnley at the City Ground from 19:45 BST.
The hosts are aiming for back-to-back Premier League wins after their 1-0 victory at Chelsea last time out, while Vincent Kompany's Burnley are looking for their first points of the season.
Eddie Howe will be discussing Newcastle United's return to the UEFA Champions League as he holds his pre-match press conference, as well as provide updated injury news.
Pep Guardiola has faced the media as holders Manchester City get ready for the start of their Champions League defence.
See: 2023/24 Champions League draw
See: 2023/24 Europa League and Europa Conference League draw
Tuesday
Newcastle will play their first Champions League match for 20 years, facing AC Milan at San Siro at 17:45 BST, while Man City host Red Star Belgrade at 20:00 BST.
See: Quiz on Newcastle's last UCL side
Erik ten Hag and Mikel Arteta will take their turns to answer the media's questions ahead of them leading their clubs back into the UEFA Champions League on Wednesday.
Wednesday
Arsenal will play their first Champions League match since 2016/17 as they entertain PSV Eindhoven at Emirates Stadium from 20:00 BST.
Manchester United have also returned to Europe's top table after missing out last season and face a testing first encounter, taking on Bayern Munich and Harry Kane in Germany at 20:00 BST.
Roberto De Zerbi, Unai Emery, Jurgen Klopp and David Moyes will also be holding press conferences to discuss their teams' own UEFA matches on Thursday.
Thursday
Brighton & Hove Albion's dream European debut will start with a home match against AEK Athens in the UEFA Europa League at The Amex Stadium at 20:00 BST.
Aston Villa continue their continental adventure after thrashing Hibernian in the UEFA Europa Conference League playoff round, with Emery's side taking on Legia Warsaw in Poland at 17:45 BST.
West Ham United look to take their strong Premier League start into Europe and enjoy another long run after winning last season's Europa Conference League, welcoming Serbia's Backa Topola to the London Stadium at 20:00 BST.
Liverpool, participating in the UEFA Europa League for the first time since 2016, travel to Austrian side LASK, starting at 17:45 BST.
In the Premier League, some clubs' managers will be holding their press conferences ahead of the weekend's fixtures.
Friday
The remaining Premier League managers will face the media, providing the latest injury and fitness news.
Saturday
Matchweek 6 of the Premier League starts at a slightly later time of 15:00 BST (giving Fantasy Premier League managers some extra hours to sort out their teams, with a deadline of 13:30 BST), but also a later finish.
The 10 fixtures are split evenly across the two days, with five on Saturday, as Man City look to extend their winning start to six matches as they welcome Forest.
Burnley welcome Man Utd in a 20:00 BST start to finish the day.
Sunday
The standout fixture of the weekend takes place on Sunday 14:00, with the first north London derby of the season.
The dream start for Ange Postecoglou and Tottenham Hotspur will be severely tested by the Gunners. Both teams have yet to taste defeat in 2023/24, making this meeting the first in the Premier League era where the two teams remain unbeaten.