Football writer Ben Bloom looks at this week's UEFA competition matches featuring Premier League sides and what we can expect from them.
After heading off on their travels around the continent last week, the six-strong Premier League contingent return to home soil for their last-16 second legs in the UEFA Champions League, UEFA Europa League and UEFA Conference League.
Arsenal are in the most comfortable position after a comprehensive 7-1 win at PSV Eindhoven, while their north-London rivals Tottenham Hotspur were the only English side to lose.
As well as looking to secure a quarter-final berth, the teams will also be playing to help the Premier League earn an additional spot in next season’s Champions League.
Here is all you need to know about the crucial second legs.
Champions League
Liverpool v Paris St-Germain (agg: 1-0)
11 March, 20:00 GMT
Given that one of these teams cruised through the league phase in top spot, while the other required three successive wins to avoid early elimination, few would have predicted what emerged at the Parc des Princes last week.
Ultimately, it was Liverpool who returned to Anfield with a first-leg lead. But there was no denying just how unlikely that victory seemed for all of that opening encounter.
PSG’s domination was absolute, dictating the entirety of the game, having 70 per cent of the possession, and attempting 27 shots compared to Liverpool’s two.
However, the hosts could find no route past an inspired Alisson Becker, who produced what he determined was the best performance "probably of my life", repelling PSG with nine saves.
That kept the match goalless until Harvey Elliott scored an unlikely Liverpool winner just 46 seconds after coming off the bench. It was the ultimate smash-and-grab win, with the Premier League leaders riding their considerable luck on various occasions.
PSG forwards Ousmane Dembele, Khvicha Kvaratskhelia and Bradley Barcola were superb, causing plenty of problems with their speed and movement.
Arne Slot confirmed he instructed his players to alter their approach at half-time, dropping deeper and packing their own penalty area.
"In the first half, we asked to press a bit more," said Slot. "In the second, they were still threatening, but most of their shots were from distance."
It worked, with Liverpool grinding out the win. But they will not want to repeat the tactic at Anfield.
Slot will demand his team take better care of the ball and build slower than they did in Paris, where they primarily adopted a long-ball approach.
Liverpool's head coach was able to use six substitutes in the Premier League win against Southampton on Saturday, rotating players to keep them as fresh as possible for this second leg.
Victory over PSG would give Liverpool a quarter-final tie against the winner of Club Brugge v Aston Villa.
Aston Villa v Club Brugge (agg: 3-1)
12 March, 20:00 GMT
Having guided Sevilla to three UEFA Europa League titles and Villareal to one, Unai Emery knows what it takes to triumph in Europe.
The Aston Villa manager is adamant that his side are not through to the quarter-finals yet, but two late goals in Belgium last week made it likely that they will be.
It was not a vintage display against the lowest-ranked side from the league phase to make it this far, but there was a sense of redemption after losing 1-0 in Brugge earlier in the season.
No one felt that more than Tyrone Mings, whose freak handball had gifted the hosts the decisive penalty in that first encounter in the league phase. In the rematch, he provided the headed assist for Leon Bailey’s opener after less than three minutes, and later pulled off a mind-boggling goal-line clearance to keep the score 1-1 in the second half.
At that stage, most Villa fans would have settled for a draw. Emery’s quadruple substitution on 64 minutes betrayed his unease at his side’s performance.
One of the men sent on was Marco Asensio, a player who won the Champions League three times with Real Madrid, and who scored Villa’s third goal from the penalty spot after an own goal by Brandon Mechele had restored their lead.
After the game, Emery pointed out that Brugge scored three goals away from home in the second leg of the knockout phase play-offs to beat Atalanta.
But Villa have been formidable at home for some time, only losing twice since last March and not since October.
Arsenal v PSV Eindhoven (agg: 7-1)
12 March, 20:00 GMT
After an evening of total domination in Eindhoven last week, Arsenal have the luxury of welcoming their Dutch opposition to Emirates Stadium with their route to the quarter-finals all but assured.
Belying their recent goalscoring troubles in the absence of various attacking players, the scoresheet featured no fewer than six different Arsenal names as Mikel Arteta’s side ran riot.
Ethan Nwaneri and Myles Lewis-Skelly also made history as the first pair of English teenagers to combine for a goal in Champions League history.
It all means any sense of jeopardy has disappeared ahead of this second leg, with PSV requiring something extraordinary to overturn their deficit in north London.
In contrast to their serene European progress, Arsenal’s quest for domestic glory has hit the ropes of late and they failed to beat Manchester United on Sunday to make it three Premier League matches without a win.
The best news from that game was the return of Gabriel Martinelli from injury, who emerged off the bench in the second half and may well be involved this week. The big positive for Arteta is that the scoreline means he need not take any risks with the Brazilian.
A trip to Madrid awaits, for a quarter-final against the winner of the Real v Atletico last-16 encounter.
Europa League
Manchester United v Real Sociedad (agg: 1-1)
13 March, 20:00 GMT
Man Utd remain favourites to reach the Europa League's last eight, but there was a sense of what might have been after last week’s trip to Spain.
The Premier League side were comfortable for more than an hour against a team who have not progressed beyond this stage of any European competition since 1989.
Joshua Zirkzee’s first European goal for United gave the visitors a deserved lead, and Andre Onana did not have a save to make until a handball decision against Bruno Fernandes gifted Real Sociedad a penalty, converted by Mikel Oyarzabal.
Thereafter, the hosts looked the far more threatening side, with Onana required to keep things level by producing a couple of wonderful saves.
United’s problems were nothing new. Deploying a front three of Rasmus Hojlund, flanked by Zirkzee and Alejandro Garnacho, they repeatedly failed to find the killer final pass and/or finish off their moves.
"It is clear we have to be more clinical," said Ruben Amorim. "We’re creating chances. Sometimes you don’t see that because we manage not to shoot. Sometimes we are missing something."
Tottenham Hotspur v AZ Alkmaar (agg: 0-1)
13 March, 20:00 GMT
Like Man Utd, Spurs' hopes of salvaging anything from a disappointing season lie in this competition, and they face an uphill challenge after a limp display in the Netherlands.
That their deficit is no greater than one goal was rather fortunate, with Ange Postecoglou admitting that "the result was probably the best thing" to come from his side’s first-leg performance.
Lucas Bergvall was unlucky to slice an attempted clearance into his own net for the game’s only goal, but the visitors were second best throughout, managing just one late shot on target.
If Spurs are to stay in the competition, it will require wholesale improvements all over the pitch. "It wasn’t good," admitted Postecoglou.
Handily, the Spurs manager will have some additional firepower to call upon. Cristian Romero and Micky van de Ven may well reunite in central defence, while Dominic Solanke is available to lead the line after only being fit enough for a 17-minute substitute appearance in the first leg.
Mathys Tel was ineffective in that role in the first leg, taken off at half-time with Son Heung-min moved central. That shift had little positive impact though.
Conference League
Chelsea v Copenhagen (agg: 2-1)
13 March, 20:00 GMT
Such is Chelsea’s superior strength to almost every UEFA Europa Conference League opponent that Enzo Maresca was able to take a gamble in the opening leg against Copenhagen, see it fail, make a raft of subsequent alterations, and still register a relatively comfortable win.
It could, and probably should, have been by a wider margin, had they not allowed Gabriel Pereira to pull a late goal back for the hosts. But there was little in the first leg to suggest that Chelsea will face a major threat at Stamford Bridge this Thursday.
Maresca gave starts to the likes of Tyrique George, Kiernan Dewsbury-Hall and 17-year-old Shumaira Mheuka, in an experiment that did not pay off.
After his team failed to register a shot on target in the first half, Chelsea's head coach made a triple substitution at the break, resulting in goals from Reece James and Enzo Fernandez.