Tottenham Hotspur are aiming to return to winning ways after their derby defeat to Arsenal, while Southampton will seek to build on their draw against Manchester United in the wake of Mark Hughes's departure.
Team news
Spurs defender Kieran Trippier (groin) is available for selection after returning to training.
Jan Vertonghen is suspended while Mousa Dembele (ankle), Davinson Sanchez (hamstring) and Victor Wanyama (knee) are also out. Erik Lamela (thigh) is a doubt.
Southampton will be without Mario Lemina (suspended) and and young striker Michael Obafemi (hamstring) who pulled up during his Premier League debut against Manchester United.
Ryan Bertrand (back), Matt Targett (head) and Danny Ings (thigh) are being assessed.
Did you know?
Spurs have won eight of their last 10 PL home matches against Southampton, losing only in September 2003 and May 2016.
Harry Kane has scored six goals in his last five PL matches against Southampton, including a hat-trick in this fixture last season.
Dele Alli has had a hand in eight goals in five PL matches against Southampton, with five goals and three assists, more than he has against any other side.
Stuart Armstrong, who has scored three goals in his last two PL matches for Southampton, could now become the first player to score in three consecutive appearances for Saints in the competition since Manolo Gabbiadini in March 2017.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Paul Tierney