Watford, who are 17th, have the chance to move three points above the relegation zone with a win.
Third-placed Leicester City will hope to consolidate their spot in the top four, but the Foxes have failed to win any of their last three away matches.
Team news
Nigel Pearson reports no fresh injury concerns for Watford with Gerard Deulofeu (cruciate ligament), Daryl Janmaat (knee) and Isaac Success (Achilles) remaining long-term absentees.
Leicester's Dennis Praet (calf) will be assessed ahead of Saturday’s match, but Ryan Bennett and Ayoze Perez are fit and available for selection.
Did you know?
Troy Deeney has been involved in six goals in his last six Premier League home matches, scoring four and assisting two. This is the same total he achieved in 25 previous fixtures at Vicarage Road.
Only Liverpool, with 18, have collected more points in home matches than Watford's 13 since the arrival of Nigel Pearson.
Jamie Vardy can become the 29th player to score 100 Premier League goals and the 16th player to do it for a single club.
Leicester have won just two of their last 10 Premier League matches at Watford, with their most recent victory during their 2015/16 title-winning campaign.
Match officials
Referee: Craig Pawson. Assistants: Daniel Cook, Dan Robathan. Fourth official: Gavin Ward. VAR: Andy Madley. Assistant VAR: Andy Garratt. Replacement official: Sam Lewis.